インフルエンザウイルス

インフルエンザウイルスは、毎年季節性の流行を引き起こす呼吸器疾患の主要な病原体であるほか、新型インフルエンザウイルスの出現によって新たな世界的流行をもたらすこともあります。

インフルエンザウイルスのゲノムRNAとそれを包む核タンパク質からなる複合体（ヌクレオカプシド）や、ウイルス粒子構成因子の構造と機能を、分子ウイルス学的な視点から解析しています。

関連論文

Masahiro Nakano, Yukihiko Sugita, Noriyuki Kodera, Sho Miyamoto, Yukiko Muramoto, Matthias Wolf, Takeshi Noda. “Ultrastructure of Influenza Virus Ribonucleoprotein Complexes during Viral RNA Synthesis” Communications Biology 4(1), 858 (2021).
Tokiko Watanabe, Eiryo Kawakami, Jason E Shoemaker, Tiago J S Lopes, Yukiko Matsuoka, Yuriko Tomita, Hiroko Kozuka-Hata, Takeo Gorai, Tomoko Kuwahara, Eiji Takeda, Atsushi Nagata, Ryo Takano, Maki Kiso, Makoto Yamashita, Yuko Sakai-Tagawa, Hiroaki Katsura, Naoki Nonaka, Hiroko Fujii, Ken Fujii, Yukihiko Sugita, Takeshi Noda, Hideo Goto, Satoshi Fukuyama, Shinji Watanabe, Gabriele Neumann, Masaaki Oyama, Hiroaki Kitano, Yoshihiro Kawaoka. “Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development” Cell Host & Microbe 16(6), 795–805 (2014).
Yukihiko Sugita, Hiroshi Sagara, Takeshi Noda, Yoshihiro Kawaoka. “Configuration of Viral Ribonucleoprotein Complexes within the Influenza A Virion” Journal of virology 87(23), 12879–12884 (2013).
Tokiko Watanabe, Maki Kiso, Satoshi Fukuyama, Noriko Nakajima, Masaki Imai, Shinya Yamada, Shin Murakami, Seiya Yamayoshi, Kiyoko Iwatsuki-Horimoto, Yoshihiro Sakoda, Emi Takashita, Ryan McBride, Takeshi Noda, Masato Hatta, Hirotaka Imai, Dongming Zhao, Noriko Kishida, Masayuki Shirakura, Robert P de Vries, Shintaro Shichinohe, Masatoshi Okamatsu, Tomokazu Tamura, Yuriko Tomita, Naomi Fujimoto, Kazue Goto, Hiroaki Katsura, Eiryo Kawakami, Izumi Ishikawa, Shinji Watanabe, Mutsumi Ito, Yuko Sakai-Tagawa, Yukihiko Sugita, Ryuta Uraki, Reina Yamaji, Amie J Eisfeld, Gongxun Zhong, Shufang Fan, Jihui Ping, Eileen A Maher, Anthony Hanson, Yuko Uchida, Takehiko Saito, Makoto Ozawa, Gabriele Neumann, Hiroshi Kida, Takato Odagiri, James C Paulson, Hideki Hasegawa, Masato Tashiro, Yoshihiro Kawaoka. “Characterization of H7N9 Influenza A Viruses Isolated from Humans” Nature 501(7468), 551–555 (2013).
Takeshi Noda, Yukihiko Sugita, Kazuhiro Aoyama, Ai Hirase, Eiryo Kawakami, Atsuo Miyazawa, Hiroshi Sagara, Yoshihiro Kawaoka. “Three-Dimensional Analysis of Ribonucleoprotein Complexes in Influenza A Virus” Nature communications 3, 639 (2012).
Yukihiko Sugita, Takeshi Noda, H Sagara, Hiroshi Sagara, Y Kawaoka, Yoshihiro Kawaoka. “Ultracentrifugation Deforms Unfixed Influenza A Virions” Journal of General Virology 92(11), 2485–2493 (2011).