生体膜タンパク質
生体膜タンパク質は細胞内外のシグナル伝達や物質輸送を担い、創薬標的としても重要な分子群です。
また、細菌毒素の中には細胞膜に結合して孔(ポア)を形成し、細胞を傷害するものもあります。
生体膜タンパク質を対象に、その構造と機能の関係の解明を目指しています。
関連論文
- Yamada T, et al. “Step-by-Step Maturation Mechanism of the Binary Toxin Pore Revealed by Cryo-EM Analysis” Proceedings of the National Academy of Sciences 123(40), e2627537123 (2026).
- Ohashi S and Katayama K and Kojima A and Yang X and Fukuda M, et al. “Structural Insights into Spectral Tuning and Retinal Exchange in Cone Visual Pigments” Science 392(6805), eadz3996 (2026).
- Suno-Ikeda C and Nishikawa R and Suzuki R, et al. “Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor” Nature Communications 16(1) (2025).
- Yamauchi M, et al. “Structural Insights into the G-protein Subtype Selectivity Revealed by Human Sphingosine-1-Phosphate Receptor 3–Gq Complexes” Proceedings of the National Academy of Sciences 122(47) (2025).
- Im D and Jormakka M and Juge N, et al. “Neurotransmitter Recognition by Human Vesicular Monoamine Transporter 2” Nature Communications 15(1) (2024).
- Im D and Kishikawa J, et al. “Structural Insights into the Agonists Binding and Receptor Selectivity of Human Histamine H4 Receptor” Nature Communications 14(1) (2023).
- Suno R and Sugita Y and Morimoto K, et al. “Structural Insights into the G Protein Selectivity Revealed by the Human EP3-Gi Signaling Complex” Cell Reports 40(11), 111323 (2022).
- Liu S, et al. “Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit” Molecules 26(18), 5462 (2021).
関連Notes
- 2026-09-28 共著論文が出版されました:ウェルシュ菌が産生する二成分毒素ポアの段階的成熟機構
- 2026-06-25 共著論文が出版されました:錐体視物質のスペクトル調整とレチナール交換の構造基盤