生体膜タンパク質
生体膜タンパク質は細胞内外のシグナル伝達や物質輸送を担い、創薬標的としても重要な分子群です。
生体膜タンパク質を対象に、その構造と機能の関係の解明を目指しています。
関連論文
- Sayaka Ohashi, Kota Katayama, Asato Kojima, Xuchun Yang, Masahiro Fukuda, Filippo Sacchetta, Ryoji Suno, Yukihiko Sugita, Nipawan Nuemket, Suhyang Kim, Kazuhiro Kobayashi, Hiroo Imai, So Iwata, Eriko Nango, Takuya Kobayashi, Takeshi Noda, Massimo Olivucci, Hideaki E. Kato, Hideki Kandori. “Structural Insights into Spectral Tuning and Retinal Exchange in Cone Visual Pigments” Science 392(6805), eadz3996 (2026).
- Chiyo Suno-Ikeda, Ryo Nishikawa, Riko Suzuki, Shun Yokoi, Seiya Iwata, Tomoyo Takai, Takaya Ogura, Mika Hirose, Akihisa Tokuda, Risako Katamoto, Akitoshi Inoue, Eri Asai, Ryoji Kise, Yukihiko Sugita, Takayuki Kato, Hiroshi Nagase, Ayori Mitsutake, Tsuyoshi Saitoh, Kota Katayama, Asuka Inoue, Hideki Kandori, Takuya Kobayashi, Ryoji Suno. “Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor” Nature Communications 16(1) (2025).
- Momono Yamauchi, Dohyun Im, Shintaro Maeda, Tatsuya Ikuta, Masayasu Toyomoto, Hidetsugu Asada, Yukihiko Sugita, Jun-ichi Kishikawa, Takeshi Noda, Takayuki Kato, Asuka Inoue, So Iwata, Masatoshi Hagiwara. “Structural Insights into the G-protein Subtype Selectivity Revealed by Human Sphingosine-1-Phosphate Receptor 3–Gq Complexes” Proceedings of the National Academy of Sciences 122(47) (2025).
- Dohyun Im, Mika Jormakka, Narinobu Juge, Jun-ichi Kishikawa, Takayuki Kato, Yukihiko Sugita, Takeshi Noda, Tomoko Uemura, Yuki Shiimura, Takaaki Miyaji, Hidetsugu Asada, So Iwata. “Neurotransmitter Recognition by Human Vesicular Monoamine Transporter 2” Nature Communications 15(1) (2024).
- Dohyun Im, Jun-ichi Kishikawa, Yuki Shiimura, Hiromi Hisano, Akane Ito, Yoko Fujita-Fujiharu, Yukihiko Sugita, Takeshi Noda, Takayuki Kato, Hidetsugu Asada, So Iwata. “Structural Insights into the Agonists Binding and Receptor Selectivity of Human Histamine H4 Receptor” Nature Communications 14(1) (2023).
- Ryoji Suno, Yukihiko Sugita, Kazushi Morimoto, Hiroko Takazaki, Hirokazu Tsujimoto, Mika Hirose, Chiyo Suno-Ikeda, Norimichi Nomura, Tomoya Hino, Asuka Inoue, Kenji Iwasaki, Takayuki Kato, So Iwata, Takuya Kobayashi. “Structural Insights into the G Protein Selectivity Revealed by the Human EP3-Gi Signaling Complex” Cell Reports 40(11), 111323 (2022).
- Si-Si Liu, Fei Jin, Yi-Shi Liu, Yoshiko Murakami, Yukihiko Sugita, Takayuki Kato, Xiao-Dong Gao, Taroh Kinoshita, Motoyuki Hattori, Morihisa Fujita. “Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit” Molecules 26(18), 5462 (2021).
関連Notes
- 2026-06-25 共著論文が出版されました: 錐体視物質のスペクトル調整とレチナール交換の構造基盤